Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In this paper, we analyse the relation between the use of environmental data in contemporary health sciences and related conceptualisations and operationalisations of the notion of environment. We consider three case studies that exemplify a different selection of environmental data and mode of data integration in data-intensive epidemiology. We argue that the diversification of data sources, their increase in scale and scope, and the application of novel analytic tools have brought about three significant conceptual shifts. First, we discuss the EXPOsOMICS (...) project, an attempt to integrate genomic and environmental data which suggests a reframing of the boundaries between external and internal environments. Second, we explore the MEDMI platform, whose efforts to combine health, environmental and climate data instantiate a reframing and expansion of environmental exposure. Third, we illustrate how extracting epidemiological insights from extensive social data collected by the CIDACS institute yields innovative attributions of causal power to environmental factors. Identifying these shifts highlights the benefits and opportunities of new environmental data, as well as the challenges that such tools bring to understanding and fostering health. It also emphasises the constraints that data selection and accessibility pose to scientific imagination, including how researchers frame key concepts in health-related research. (shrink)

In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been conceived, developed and established in the context of contemporary epidemiological research. I argue that the exposome has been developed by transferring approaches, methods and conceptualizations from other lines of research in the life and health sciences. I thus discuss the (...) conceptual and methodological innovations of the exposome as a result of the merging and adaptation of these elements for new uses and purposes. On this basis, I argue that the novelty of the exposome should be seen in incremental rather than revolutionary terms and, in this sense, the exposome shares significant elements with other projects and repertoires in postgenomics. I conclude by discussing the consequences of this analysis for the potential limitations and future development of exposome research. (shrink)

How is scientific data used to represent phenomena and as evidence for claims about phenomena? In this paper, I propose that a specific type of claims – evidential claims – is involved in data practices to define and restrict the representational and evidential content of a dataset. I present an account of data practices in the epidemiology of the exposome based on the notion of evidential claims, which helps unpack the approaches, assumptions and warrants that connect different stages of research. (...) I identify three different strategies to generate different types of evidential claims in this case. The macro strategy, which individuates the dataset that serves as the initial evidential space for research. The micro strategy, which is used to generate evidential claims about the microscopic and individual component of target phenomena. The association strategy, that uses evidence from the other strategies to identify a dataset as representation of the different levels and relations of exposure and disease. Differentiating between these strategies sheds light on the multi-faceted landscape of biomedical research on environment and health; and the roles of data and evidence in the process of inquiry. (shrink)

Attraverso una breve e veloce premessa storico-critica e storico-filosofica il testo proposto fa emergere il tema del rapporto problematico sussistente fra l'attuale ideologia che sorregge il fenomeno economico, sociale e politico della globalizzazione internazionale dei capitali (soprattutto finanziari) ed i riflessi di ordine umano e naturale che ne sono l'effettiva conseguenza. Da un punto di vista psicologico, sociale ed educativo l'impianto ideologico neoliberista viene allora contrastato dalla ripresa di un pensiero critico, radicale e rivoluzionario, che riutilizza il principio dell'infinito creativo (...) e doppiamente dialettico, di lontana matrice presocratica e bruniana. Il testo analizza la progressione di avvicinamento a tale principio preparata dalle riflessioni di H. Marcuse, W. Reich, G. Deleuze, C. Castoriadis e A. Badiou. (shrink)

A basis for a set C of functions on natural numbers is a set F of functions such that C is the closure with respect to substitution of the projection functions and the functions in F. This paper introduces three new bases, comprehending only common functions, for the Grzegorczyk classes ℰ_n with n ≥ 3. Such results are then applied in order to show that ℰ_{n+1} = K_n for n ≥ 2, where {K_n}n∈ℕ is the Axt hierarchy.

In lieu of an abstract, here is a brief excerpt of the content:Hunters, Cooks, and Nooks:Two Interpretations of the Tangled Relationship Between Philosophy and ScienceStefano Franchi (bio)Knowledge is the measure of all things.—Plato, Prot. 361b1Preliminaries: Double QuestioningWhen philosophers ask questions about science, they usually do so in the context of one specific discipline whose latest results or whose historical development seem to pose genuinely philosophical problems: for instance, the nature of space/time, the nature of intelligence, the nature/nurture debate. It is (...) rarer to hear a philosopher asking questions about the general relationship between philosophy and science, even when, as in the cases above, the answer to this question provides the necessary ground for any specific investigation of the allegedly genuine philosophical problems arising in physics, biology, or cognitive science.The main difficulty lies in the intrinsic ambiguity of the term "science." On the one hand, "science" can be considered as a descriptive term: it is the genus of the empirically given, scientific disciplines (the "sciences," in the plural). On the other hand, "science" (episteme, scientia, Wissenschaft) (always in the singular) is a theoretical term that denotes a form of knowledge. More precisely, it refers, as philosophers say, to a "conceptually unified body of objective knowledge." Traditionally, the latter meaning includes philosophy itself within its denotation. Thus, when both meanings of the term "science" are considered, to interrogate the relationship between philosophy and science is always, and preliminarily, to question the nature of philosophy itself, even when the question as such is not explicitly raised. In all these cases, a characterization of the nature of philosophy is presupposed by a philosophical analysis of scientific results.However, unless the specificity of concrete scientific investigations is denied from the outset, the questioning, even when conducted from a circumscribed philosophical standpoint, cannot be reduced to a single gesture that interrogates the scientificity of philosophy. On the contrary, it must also concurrently question the possibility of a specific relation between a determinate philosophical endeavor and specific scientific pursuits. Any questioning of the relationship between philosophy and science will always imply a double gesture: on the one hand, a question about what makes or does not make philosophy a science; on the other, what brings philosophy closer, or moves [End Page 98] it farther apart, from the sciences. Most often, philosophers focus their attention on just one aspect of this double question. In this paper, I would like to address both sides of the issue. In particular, I would like to examine the two very different answers to this general problem given by Plato and by Michel Foucault. Although their answers address fundamentally the same issue, they are so diametrically opposed, as I will show, that they may be considered as the external boundaries of a very broad range of possible responses.2SignpostsLet me begin with Plato. In a well-known passage from the Euthydemus, the main characters are discussing which kind of knowledge is required by wisdom. In this context, to the delighted although belated surprise of Crito, the young Cleinias introduces a crucial distinction between hunters and cooks: the former know how to find the prey, but only the latter know how to use it:No art of actual hunting, [Cleinias] said, extends any further than pursuing and capturing; whenever the hunters catch what they are pursuing they are incapable of using it, but they and the fishermen hand over their prey to the cooks. And again, geometers and astronomers and calculators (who are hunters too, in a way, for none of these make their diagrams; they simply discover those which already exist), since they themselves have no idea of how to use their prey but only how to hunt it, hand over the task of using their discoveries to the dialecticians—at least, those of them who are not completely useless [anoetoi].[290b–c]1Cleinias's account acknowledges the reality and value of the knowledge gained by the sciences, but denies that scientists have full awareness of what they are doing and of the implications of their own work. Scientific knowledge lacks both self-reflexivity and transparency: it does not have the ability to bring to full evidence the principles it rests upon... (shrink)

For arbitrary finite group $G$ and countable Dedekind domain $R$ such that the residue field $R/P$ is finite for every maximal $R$ -ideal $P$ , we show that the localizations at every maximal ideal of two $RG$ -lattices are isomorphic if and only if the two lattices satisfy the same first order sentences. Then we investigate generalizations of the above results to arbitrary $R$ -torsion-free $RG$ -modules and we apply the previous results to show the decidability of the theory of (...) ${\vec Z}C(2)^2$ -lattices. Eventually, we show that ${\vec Z} [i] C(2)^2$ -lattices have undecidable theory. (shrink)

Realist ontologies about history stress that entities such as documents, their sources, and events whom they are talking about are objectively given in the ontological reality of social history, beyond our skills to recognize them. Thus, how is it possible to understand the extension of the ontological independence of historical findings and where does our (mis)interpretations of those findings begin? As every realist ontological commitment must provide us with a suitable tool to solve the age-old problem of findings’ reliability, in (...) this paper we analyze how such realist views, like Searle’s Collective Intentionality, cannot be a solution, meanwhile, on the other hand, other realist purposes could represent valid alternatives. In fact, Searle’s theory surely accounts for the constitution of such social objects as false historical acts, but its definition of function of status (FS) as “X count as Y in C” permits, even only in principle, that the same entity X, which has counted as Y, in the far-off times historical context C0, could “re-count” as Y  Y in a more recent context Ct  C0, after an involuntary forgery too. Being by definition iterative, FS could iterate clamorous twists, also ad libitum, making future historians’ shared intentionality lose the contact with the reality of original status’ functions. On the contrary, Ferraris’ Documentality satisfies this historical reliability test, because its definition of a social object as inscription of an act distinguishes between what a fact/event/object X of the past has been, and what characteristics this same X must possess to become a document, discerning, this way, voluntary from unintentional effects of the creation of an object/event/fact, to instantiate a social fact, or to cause an historical event, and their different taxa of historicity. (shrink)

The book includes 13 contributions that deal with the first attempts of opposition to the of Aristotle's thought. From Theophrastus to Epicurus, and to Plotinus. The best specialists have collaborated (among others: M. Mignucci, E. Berti, K. Ierodiakonou, C. Natali, S. Maso, F. Ferrari, D. Taormina, A. Falcon, A. Schiaparelli).

Cet article réexamine la documentation sur le sanctuaire extra-urbain d’Asklépios et le temple ionique de la terrasse du théâtre à Pergame. Ces deux cas d’étude permettent d’étudier les développements diachroniques du paysage sacré de la cité et de ses alentours pendant la « longue période hellénistique » (fin du ive s. av. J.-C. – début du iiie ap. J.-C.). Cette analyse interdisciplinaire combine les sources textuelles, archéologiques et numismatiques pour étudier la distribution topographique des cultes pour les dieux et les (...) chefs politiques, leurs relations et changements à travers le temps. Pour ce faire, plusieurs questions méthodologiques sont examinées : les critères permettant de distinguer la présence du temple d’un dieu des traces diffuses de son culte à travers le paysage urbain ; la topographie de la dissémination et du remploi des textes et des artéfacts anciens et le type d’information qu’elle livre sur leur situation et fonction originaires ; l’équilibre entre continuité et innovation dans les modèles d’intégration des cultes pour les chefs politiques dans l’espace et le temps sacrés de la communauté. L’article apporte un nouveau soutien à la thèse selon laquelle Pergame n’abrita jamais un deuxième Asklépieion à l’intérieur de ses murs. (shrink)

1. Phénoménologie et philosophie de la religion La tradition philosophique issue de Husserl, c’est un fait établi, a largement accueilli dans son propre domaine de recherche une famille de questions appartenant à un foyer virtuel que l’on peut désigner sans trop de risques – et malgré l’irréductible imprécision du terme – par le mot « religion » : Dieu, l’absolu, l’infini (avec sa gloire), le sacré, le saint, la mystique, l’incarnation, l’idole, l’icône, et même la religion en tant que telle...

The papers presented in this volume in honour of Alfonso Maieru cover some of the major topics of his research area. The institutional and intellectual life of university training in the Middle Ages, including the peculiar tradition of related works, is the focus of the papers by Louis Jacques Bataillon, William J. Courtenay, Jacqueline Hamesse, Zenon Kaluza, Loris Sturlese and Olga Weijers. Three papers, by Jacopo Costa, Pasquale Porro and Thomas Ricklin, deal with philosophical problems in Dante'sMonarchia and Convivio. The (...) complex interrelations between logic and the other main aspects of medieval philosophy, with a particular attention to theology, metaphysics and natural philosophy, are the core of the other papers by Stefano Caroti, Sten Ebbesen, Barbara Faes de Mottoni, Simo Knuuttila, Alain de Libera, Olga Lizzini, Costantino Marmo, Claude Panaccio, Ivan Bendwell, Irene Rosier-Catach, Lambert Marie de Rijk, Leonardo Sileo, Luisa Valente, and Albert Zimmermann. A larger number of friends and colleagues of Alfonso Maieru than those who appear as contributors and editors of this volume have warmly welcomed its publication. We could say, therefore, that it is absolutely contingent that the Editors are: Stefano Caroti (Universita degli Studi di Parma), Ruedi Imbach (Universite de Paris-Sorbonne), Zenon Kaluza (Centre d'Etudes des Religions du Livre, C.N.R.S), Loris Sturlese (Universita degli Studi di Lecce) and Giorgio Stabile(Universita degli Studi di Roma "La Sapienza"). (shrink)

I reconstruct Bruno Latour's ideas about science and religion and compare them to Ian G. Barbour's and Mikael Stenmark's models, as well as to the discussion of technology and religion developed by John C. Caiazza and Antje Jackelén. I show how using “Latour's App” enlightens some aspects of said models which Barbour and Stenmark themselves were seemingly struggling with, and that Caiazza's and Jackelén's views can be reconciled despite their apparent opposition. The result of such tests is an overall assessment (...) of Latour's proposal. I argue that, under the disguise of a flamboyant and original language, Latour's method is not that distant from those of the other authors analyzed here, and that his discussion might conceal some unwelcome philosophical shortcomings. (shrink)

SARS-CoV-2 vaccines are indispensable allies in the fight against COVID-19. Behavioral and cognitive scientists have argued for taking advantage of insights from their fields of investigations in shaping anti-COVID policies. B&C scientists extensively discussed the methodological and practical issues that arise in translating B&C research results into policy interventions aimed to boost vaccination, Nevertheless, the same cannot be said for the ethical aspects. In the present work, we discuss the ethics of nudging vaccination in light of the “alien control” objection, (...) a kind of control whereby an agent has the power to influence the choice of another agent, and the latter cannot control such power. We proceed as follows. We begin by presenting several cases of mandatory policies avaiable to policymakers to boost the vaccine rate. Next, we point out that insights from B&C sciences can inform mandatory policies and open up ways to enhance them. In section 3, we focus on untraditional policy tools, viz. nudges. In the second part of the article, we introduce the debate on the ethics of nudges, focusing on the “alien control” objection and its relevance for the citizens’ freedom and autonomy. We therefore discuss the original point of the paper. We argue that, referring to nudging vaccination, a somehow neglected ethical issue posed by nudges emerges. Our point is that nudges do not exert exclusively an influence over a targeted behavior. Indeed, nudges impose as well a political influence by which citizens are treated as means to succeed in achieving a peculiar, and potentially controversial, political aim. We argue that, due to what we propose to call the “political multi-justifiability" of nudges, their political influence cannot be detected by citizens. This leads to the threat of alien control. In the last section, we draw some tentative conclusions, suggest a possible solution and its practical advantages. (shrink)

What is the best way to understand the narratives of self-identity at the beginning of the 21st century? This interdisciplinary collection brings together perspectives from analytical psychology, sociology, psychiatry, psychosocial studies and psychoanalysis to consider questions about individuation and freedom in our disconnected world. The contributors discuss the meaning of, and need for, individuation in individualized and liquid societies. The book begins with a comparison of three approaches: C.G. Jung's individuation, Ulrich Beck's individualization, and Zygmunt Bauman's liquidity. This sets the (...) tone for further consideration of topics including guilt, social media, global nomads, and surveillance. Theoretical reflections are enhanced by clinical material, and the book emphasises the connections between sociology and psychoanalysis, offering significant insights into the importance of psychosocial approaches. This timely work will be of great interest to academics and scholars of psychosocial studies, Jungian studies, sociology and politics. (shrink)

La prima parte del saggio si sofferma sul conflitto e sulle possibili convergenze tra il concetto di individualismo e quello di socialismo: sebbene siano stati spesso pensati in contraddizione, individualismo e socialismo possono anche essere visti come due concetti sinergici e complementari. Ciň č possibile se si assume la validitÀ della tesi, sostenuta da autori come Guyau e Kropotkin, secondo la quale nell'autentico sviluppo dell'individuo non c'č posto per la sopraffazione ai danni dell'altro. La seconda parte dell'articolo si sofferma sul (...) rapporto fra individualismo e modernitÀ, mostrando come la modernitÀ sia stata intesa sia come l'epoca della individualizzazione, sia come il tempo della omologazione massificante; e si conclude con l'idea che la nostra epoca sia caratterizzata piuttosto da molte forme di pseudo-individualismo. (shrink)

L'articolo si sofferma su alcuni aspetti della disputa fra realismo e idealismo nella comprensione della politica. Dopo aver delineato una rapida sintesi di alcune delle principali tesi del ‘realismo politico', l'articolo mette in risalto alcune difficoltÀ interne e contraddizioni che sembrano minare la validitÀ di questo punto di vista. Ma neppure la visione normativista o kantiana della politica č priva di problemi irrisolti. Pertanto, l'autore ritiene che entrambi i punti di vista sulla politica ne colgano alcuni aspetti essenziali, e che (...) perciň la riflessione sulla politica non possa privarsi di nessuno di essi, ma passi necessariamente per la loro sempre problematica e instabile combinazione. (shrink)

La questione della decadenza dell'individuo, o addirittura della sua liquidazione nella societÀ di massa, č un teai centrale della teoria critica della societÀ di Adorno e Horkheimer, sviluppato non solo nella, ma anche in molti testi di Adorno e negli importanti scritti pubblicati ora in italiano. Il problema che emerge da tali testi č: mentre la teoria adorniana insiste fortemente sul tema della decadenza dell'individuo, la teoria sociale contemporanea sembra invece a prima vista andare in una direzione opposta. Oggi molti (...) scienziati sociali, come per esempio Zygmunt Bauman, descrivono la societÀ contemporanea come caratterizzata da crescenti processi di individualizzazione. Nasce dunque la domanda: chi ha ragione? I teorici della obsolescenza dell'individuo o quelli della crescente individualizzazione? Il testo cerca, ripartendo da Adorno, di svolgere qualche considerazione su questo tema. (shrink)

L'articolo presenta un'analisi comparativa tra le posizioni di Adorno e Nietzsche riguardo al ruolo della soggettivitÀ. Se da un lato č possibile rilevare l'affinitÀ di percorso dei due autori nel criticare la soggettivitÀ ‘costitutiva' quale risultato di un processo storico di identificazione operato dalla razionalitÀ, allo stesso tempo si evidenziano le differenze delle due prospettive in merito alle conclusioni raggiunte da tale critica. Il processo di dissoluzione della soggettivitÀ sostenuto da Nietzsche č in parte respinto da Adorno sulla base del (...) rifiuto di identificare un principio formato sulle passioni. La critica sociale di Adorno lo porta a rifiutare l'affermazione di un principio di piacere ormai ridotto alla sua versione reificata. La critica della soggettivitÀ borghese conduce Adorno all'affermazione di quello che puň essere definito un ‘oltre-borghese': una forma di soggettivitÀ non costitutiva che rispetti il non-identico. (shrink)

Recent neuro-psychoanalytic literature has emphasized the view that our subjective identity rests on ancient subcortical neuro-psychic processes expressing unthinking forms of experience, which are “affectively intense without being known” (Solms and Panksepp, 2012). Devoid of internal representations, the emotional states of our “core-Self” (Panksepp, 1998b) are entirely “projected” towards the external world and tend to be discharged through instinctual action-patterns. However, due to the close connections between the subcortical and the cortical midline brain, the emotional drives may also find a (...) way to be reflected within an intrinsic self-referential processing, evident when the organism is not actively engaged with the external world. Thanks to such endogenous functioning, the core-Self emotional dispositions are not overtly executed, but they are organized within coherent dynamic mental structures, called “feeling-toned complexes” by C.G. Jung and “unconscious phantasies” by Melanie Klein. The intrinsic self-referential dynamism of the ‘brainmind’ originated from REM sleep arousal and then evolved in the resting-state activity of a complex of cortico-limbic midline brain structures (CMS), also called Default Mode Network (DMN). From our neuro-ethological perspective, it is sustained by an “introverted” SEEKING activity leading to the subjective exploration of internally constructed virtual scenarios. This “mind wandering” function, implicated in dreaming, fantasy processing, remembering and thinking, is the essence of the imaginative function and constitutes the first form of reflection, where intentions and drives gain a primordial form of conscious (but not self-conscious) representation. During postnatal development, this original (“archetypal”) imaginative function is slowly attuned in a relational “transitional” space and may be expressed first in non-verbal and eventually in abstract-verbal social communicative patterns. Our view has noticeable implications for psychotherapy. Instead of trying to directly modify interpersonal, extrinsic relationships (a top-down approach), dysfunctional emotional-relational patterns may be modified by a process in which the patient is helped to let-go of the perceived feeling-objects in favor of an immersion, via the actual feeling, from the superficial level of perception towards a void feeling-state, empty of images. Only starting from this “anoetic” feeling-state, the deep imaginal creative and re-structuring self-referential activity may be reactivated by a process of spontaneous imagination. (shrink)

In this paper we disambiguate the design stance as proposed by Daniel C. Dennett, focusing on its application to technical artefacts. Analysing Dennett’s work and developing his approach towards interpreting entities, we show that there are two ways of spelling out the design stance, one that presuppose also adopting Dennett’s intentional stance for describing a designing agent, and a second that does not. We argue against taking one of these ways as giving the correct formulation of the design stance in (...) Dennett’s approach, but propose to replace Dennett’s original design stance by two design stances: an intentional designer stance that incorporates the intentional stance, and a teleological design stance that does not. Our arguments focus on descriptions of technical artefacts: drawing on research in engineering, cognitive psychology and archaeology we show that both design stances are used for describing technical artefacts. A first consequence of this disambiguation is that a design stance, in terms of interpretative assumptions and in terms of the pragmatic considerations for adopting it, stops to be a stance that comes hierarchically between the physical stance and the intentional stance. A second consequence is that a new distinction can be made between types of entities in Dennett’s approach. We call entities to which the intentional designer stance is applied tools and entities to which the teleological design stance is applied instruments, leading to a differentiated understanding of, in particular, technical artefacts. (shrink)

Lazare Carnot was the unique example in the history of science of someone who inadvertently owed the scientific recognition he eventually achieved to earlier political prominence. He and his son Sadi produced work that derived from their training as engineers and went largely unnoticed by physicists for a generation or more, even though their respective work introduced concepts that proved fundamental when taken up later by other hands. There was, moreover, a filial as well as substantive relation between the work (...) of father and son. Sadi applied to the functioning of heat engines the analysis that his father had developed in his study of the operation of ordinary machines. Specifically, Sadi's idea of a reversible process originated in the use his father made of geometric motions in the analysis of machines in general. (shrink)

It is shown that the Maxwell-Lorentz equations can be deduced from the law of Biot-Savart by simply performing some theoretical experimentations.

Previous studies have found Forsyth’s Ethical Position Questionnaire (EPQ) to vary between countries, but none has made a systematic evaluation of its psychometric properties across consumers from many countries. Using confirmatory factor analysis and multi-group LISREL analysis, this paper explores the factor structure of the EPQ and the measurement equivalence in five societies: Austria, Britain, Brunei, Hong Kong and USA. The results suggest that the modified scale, measuring idealism and relativism, was applicable in all five societies. Equivalence was found across (...) Britain, Brunei and USA, but the original scale cannot be used validly. (shrink)

This essay explores the treatment of the relation between nature (phusis) and norm or convention (nomos) in Democritus and in certain Platonic dialogues. In his physical theory Democritus draws a sharp contrast between the real nature of things and their representation via human conventions, but in his political and ethical theory he maintains that moral conventions are grounded in the reality of human nature. Plato builds on that insight in the account of the nature of morality in the myth in (...) the Protagoras. That provides material for a defense of morality against the attacks by Callicles in the Gorgias and Thrasymachus and Glaucon in the Republic, all of whom seek to use the nature-convention contrast to devalue morality. (shrink)